Newport-City 2029: Major, an advanced female cyborg, is in charge of the anti-terrorism etc. unit reporting directly to the government. Taking out terrorists and freeing hostages at an embassy doesn't go smoothly. Major investigates why.

In the year 2027, a year following the end of the non-nuclear World War IV, a bomb has gone off in Newport City, killing a major arms dealer who may have ties with the mysterious 501 Organization. Public Security official Daisuke Aramaki hires full-body cyber prosthesis user and hacker extraordinaire, Motoko Kusanagi, to investigate.