- Maaya Sakamoto
- Motoko Kusanagi
- Ken'ichirô Matsuda
- Batou
- Ikkyû Jaku
- Daisuke Aramaki
- Kazuya Nakai
- Borma
- Kenji Nojima
- Tsumugi
- Mayumi Asano
- Kurutsu
- Megumi Han
- Chris
- Miyuki Sawashiro
- Logicoma
- Mugihito
- Robert Lee
- Naoto
- Osamu Fujimoto
- Shunsuke Sakuya
- Ishikawa
- Takurou Nakakuni
- Saito
- Tarusuke Shingaki
- Togusa
- Yôji Ueda
- Paz
- Atsushi Miyauchi
- (voice)
- Felecia Angelle
- Tsumugi (young)
- Philip Annarella
- Additional Voices
- Dawn M. Bennett
- Additional Voices
- Z. Charles Bolton
- Administrator of Protective Institution
- Bradley Campbell
- Robert Lee
- Patric Carroll
- Additional Voices
- Clifford Chapin
- Additional Voices
- Dallas Clifton
- Additional Voices
- Cynthia Cranz
- Kitahara
- Kul Das
- Additional Voices
- Aaron Dismuke
- Additional Voices
- Jason Douglas
- Paz
- Cris George
- Additional Voices
- Kenny Green
- Richard Wong
- Jessie James Grelle
- Additional Voices
- Chris Guerrero
- Akiyama
- Sean Hennigan
- Akira Fujimoto
- Jeremy Inman
- Additional Voices
- Jeff Johnson
- Additional Voices
- David Matranga
- Osamu Fujimoto
- Elizabeth Maxwell
- Motoko Kusanagi
- Robert McCollum
- Koichi Sawada
- Mary Elizabeth McGlynn
- Kurutsu
- Kristen McGuire
- Additional Voices
- Skyler McIntosh
- Additional Voices
- Patrick Morphy
- Additional Voices
- Trina Nishimura
- Chris
- Alex Organ
- Togusa
- Phil Parsons
- Borma
- Daniel Penz
- Amagata
- Kyle Phillips
- Additional Voices
- Brandon Potter
- Ishikawa
- Chris Rager
- Ibachi
- Aaron Roberts
- Vice-Minister of Commerce Ito
- Michelle Rojas
- Additional Voices
- Christopher Sabat
- Batou
- Jad Saxton
- Logicoma
- Ian Sinclair
- Additional Voices
- Marcus D. Stimac
- Saito
- John Swasey
- Daisuke Aramaki
- Eric Vale
- Tsumugi
- David Wald
- Raizo
- Kent Williams
- Kuwahara
- Brian Witkowicz
- Additional Voices
