Yuji Kaido was diagnosed with a serious disease and since there was no cure for the unknown illness, he was cryogenically frozen.

Yuji Kaido was diagnosed with a serious disease and since there was no cure for the unknown illness, he was cryogenically frozen. Twenty years later, he wakes up to see the Earth like it has never been before-the humanity is almost eradicated, because of the alien bugs called the Blue. However, the humanity still lives, a few selected humans have retreated to the space station called Second Earth. Yuji is taken back to the Second Earth, where he finds out that there are people that have been also cryogenically frozen and now they will be used as a force to combat the Blue.—Scientiiaa

Blue Gender takes place in the not too distant future in a world where things have gone terribly wrong for humanity. Humans have been replaced at the top of the food chain by the Blue, a race of bug-like aliens that have colonized Earth and pushed humans aside. A space station, Second Earth, has been constructed as a safe haven for humans, with the hope of one day reclaiming the Earth once more. Yuji Kaido was cryogenically frozen, having been suffering from a disease known as B-Cells. Once awakened, he joins a team of soldiers that have come to Earth to extract him. Unfortunately, nothing goes according to plan as they make their way back to Second Earth. Yuji will have to deal with the horrors of fighting a bloody war as he and the fighters from Second Earth look to survive. Will they be able to win back Earth without losing their humanity?

The year is 2031, and after being in cold-sleep for twenty-two years, Yuji Kaido wakes up in the middle of a war for human survival against giant insects called the Blue, who have overrun the Earth and have killed almost the entire population.—fml_lopez