Ironside becomes embroiled in a scandal, both personal and professional, when a scandal rag prints a story by a lady of the evening claiming he had slept with her and that he failed to properly work a case.
A friend of Fran's finds her only son dead in his locked room. The death is initially presumed a suicide, but assorted clues make his death look more like murder.
An old love of Ironside comes back to town after a number of years. Ironside is sure he knows why she's back and it may involve the theft of a valuable piece of art.
A think tank group has been working on military assignments. A member who was having second thoughts about working on military projects becomes missing. Is he a spy or a defector? Only Ironside can solve the mystery.
A couple vanishes after spending the night in a haunted house. Then Ironside suddenly disappears. Can the rest of the gang figure out what happened and who did it?
Fran discovers that her maid is an illegal immigrant. The maid's sister dies because of the organization controlling the illegal workers. The organization wants to kill the maid before she contacts the police. Then a member of the organization is stabbed to death. Did the maid kill the man for revenge of her sister's death? Will the illegal group treating immigrants like slaves be shut down? Only Ironside will get to the bottom of it.
Two part episode. A boy witnesses a murder of a campaign manager for a politician just before an election. There is a leak inside the police department. Ironside retires from his job and poses as a drunk and a bum. Ironside meets new "friends" and one of them tries to poison Ironside before he can find the leak in the police department.
A psychic performing in a nightclub knows suspiciously specific details about a string of arson fires. He insists he's innocent of the crimes and wants only to help capture the real arsonist. Can he overcome Ironside's ironclad skepticism?
A returning POW from Vietnam believes he saw his father at the airport. The man is supposed to be dead and since he was a decorated police officer, Ironside decides to investigate.
When two men are killed in a robbery, Ironside reluctantly turns to a long dormant informant. His involvement not only threatens his life but also his wife's and daughter's.
After a slam dunk case goes bad in court Ironside discovers a package of heroin critical to the case has gone missing. Lt. Reese and his partner become suspects and when his partner suddenly dies, Reese becomes the main suspect.
When Ironside returns to his home town for his class reunion, he is drawn into solving the murder of his former classmate but soon the murderer targets Ironside.
While driving his van Ironside is struck by a woman while she is having a mild heart attack. Once in the hospital they discover her problem was caused by a bullet but she has no memory of being shot.
While Ed is escorting a prisoner back to San Francisco the plane has to detour to another airfield. It gets even worse when he realizes there's a killer after them.
A doctor is suspicious of the in-flight death of a private pilot. The quirky doctor, who likes to mix up various home-brewed alcoholic beverages such as green bourbon, and Ironside make a good team as they try to figure out what would cause the pilot's heart attack at the controls (his wife brought the plane down with much difficulty). The only major clue is a thermos with a glass inside, which shattered while the plane was still in the air.
