Holmes and Watson's new careers as consultants for Scotland Yard in London take them inside the tabloid journalism industry when a model is the victim of an acid attack.
Holmes and Watson try to work a stateside investigation from London when someone close to them is gravely wounded by an unknown perpetrator in the U.S.; Holmes' stateside legal trouble threatens to derail their efforts.
Holmes takes extreme measures to gain legal re-entry into the U.S.; Watson helps the NYPD investigate a murder at a storage facility that caters to wealthy clients with items they want hidden from customs agents.
After an explosion at a traffic stop, Holmes and Watson must determine whether the attack was a terrorist attack; Holmes and Watson suspect there is more for them to discover regarding the recent attack.
Holmes and Watson must find the connection between three unrelated murders. Billionaire Odin Reichenbach suspects he is being threatened by someone in his own company and hires Holmes and Watson to find the perpetrator.
Tech billionaire Odin Reichenbach presents Holmes and Watson with an extraordinary offer to help him with a program that can predict future crimes. Also, Holmes and Watson assist Bell when he tries to prevent a future crime of his own, as he races to locate a fellow NYPD officer planning a sniper shooting.
Holmes and Watson investigate the murder of a criminal who made his living by stealing from other criminals. Captain Gregson resumes leadership of the precinct, and suspects his interim replacement, Captain Dwyer, is responsible for one of his best detective's suspicious departure.
In the wake of a sculptor's murder in New York, Holmes and Watson must determine whether a long dormant serial killer has resurfaced; Watson suspects Holmes is keeping something from her.
Holmes and Watson's foe, Odin Reichenbach, asks them to test his new crime prevention system; tasked with investigating someone the program predicts will commit a crime, they worry Odin will take drastic action.
In the series' finale, Holmes and Watson battle with tech billionaire Odin Reichenbach and receive word of their old enemy and Sherlock's former love, Jamie Moriarty.