A Sudanese boy adopted by a high-profile New York couple disappears, and it is connected to a Sudanese man trying to extort the couple, claiming that he is the child's biological father.
A crime scene cleaner and his daughter are missing, and the case is connected to the daughter's possible sexual assault, and her self-esteem issues about being considered overweight.
A television reporter's disappearance is tied to her son's torture and death in a Guatemala prison. Jack is forced to bring in the CIA to help crack the case.
A young woman disappears after her boyfriend is killed in a police shooting. Agents believe the disappearance is connected to the girl's brother, a notorious gang leader who had a falling-out with her.
When a serial killer eludes capture in Nevada and escapes with his son to New York City, the crew picks up the trail with the help of Las Vegas CSI's Gil Grissom. Part two of a crossover with "CSI: Crime Scene Investigation."
A college student disappears after his racist statements are posted on an Internet video site, but the case reveals a secret about the student's racial identity and his real father.
While the team investigates the disappearance of an ex-con who served time for embezzlement, Agent Johnson gets a possible break in her case involving the kidnapping of a young woman.
The disappearance of a VA hospital worker takes an unexpected turn when the FBI discovers that she's part of a plot to blow up a military building on a college campus.
While Jack fights for his life, the team takes on a case involving the disappearance of a teenage heart transplant recipient who was looking for information about the boy whose heart she received.
A despised businessman who wakes up from a coma after three years disappears, and Jack leaves the hospital to come to the aid of a young girl in danger.
The team discovers that a missing woman recently won $32 million in the lottery, but was it her ticket? Meanwhile, Jack begins investigating the father of Samantha's child.
The team searches for a good Samaritan tow-truck driver who is running from and seeking redemption for a horrific episode from his past, and the bureau appoints Jack a psychiatrist.
