The network executive assigned to retool the show has gone too far with his changes, and Larry's agent betrays him. Upset with all that is going on, Larry announces to his audience that he will be leaving the show when his contract expires.
With the show winding down, everyone begins trying to secure future jobs. Hank is the most worried about his future, especially after auditioning for a job as a game show host and appearing on Caroline In The City.
Larry embarrasses himself during an interview and enlists Arthur to help him get it edited. Mary Lou hits Hank's car and ends up on a date with him when she has trouble telling him about it. Hank gets in trouble when he blames Vince Vaughn.
The network is furious after guest host, Jon Stewart, writes a sketch starring Hank, as Hitler, and invites The Wu Tang Clan to perform on the show. Larry's brother comes to visit.
Beverly is pregnant, and it turns out that one of the guests on the show is the father. While Larry and the staff try to figure out who it is, Hank spends a week in Wisconsin with a married couple for a new segment.
Hank blames himself for the recent suicide of Larry's cue card man, Sid, because of some hurtful things he said after a rehearsal. Larry tries to keep his relationship with guest, Laura Dern, a secret from the staff and his audience.
Friendships are tested when Larry wants to date Jeff Goldblum's ex, Gina Gershon, and Mary Lou agrees to book Wendy on the show. Hank falls for the female doctor that gives him his first colonoscopy.
Brian can no longer take Phil's homophobic jokes and threatens to sue the show for sexual harassment. Larry's tests his girlfriend, actress Illeana Douglas' guest appeal. Hank prepares celebrity farewell videos for Larry's departure.
