Alan goes up against an ex who got away and he's not completely over in a case against Big Tobacco, and Denny is too busy to help because he's worried about his impotence problem.
Jerry and Katie take a case involving a 15-year-old who claims a guard raped her in a private prison, Shirley's 17-year-old granddaughter is in trouble for voting in the primary, and Alan and Denny take on the pharmaceutical industry.
Denny faces concealed weapons charges after he shoots a mugger, and Alan confronts his own sexism as he represents a sexual surrogate in a child custody case.
Being noted as a great lawyer attracts the attention of a former girlfriend as she asks Alan to defend her husband in a murder trial, even though he still has feelings for her which compounds the case in a conflict of interest.
A judge finds out that Alan bet with Denny on the outcome of his case involving malpractice at a military hospital. Jerry takes a sperm bank to court to find out if his nephew and his new girlfriend have the same sperm donor.
Alan and Denny vacation at a dude ranch in Utah and wind up facing adultery charges, but an unlikely ally comes to their defense. Back in Boston, Shirley defends Catherine Piper, who is accused of attempting to murder her doctor.
While Jerry goes up for partner, Alan goes head-to-head with Denise Bauer in a case involving government Mad Cow Disease testing, and head-to-head with Denny over his decision to vote for John McCain.
Alan and Shirley confront their own misgivings about legalized abortion as they defend a 15-year-old Chinese immigrant who wants one. Meanwhile, Jerry faces assault charges after punching out a man in a coffee shop who ridiculed him.
Denny and Carl go to Virginia to defend a corrections officer who shot and killed an inmate during his botched execution, and Alan and Shirley defend one of Alan's old classmates who says she was fired because she voted for John McCain.
Different topics abound at Shirley's house for Thanksgiving when the gang assembles for what was supposed to be a quiet intimate dinner for two between her and Carl.
Alan helps Denny fight for the right to take a still-unapproved Alzheimer's drug, Carl helps Catherine Piper sue the networks for ageism, and Jerry and Katie take a case involving "academic doping."
As Alan prepares to try Denny's Alzheimer's drug case in front of the Supreme Court, Shirley tries to block the purchase of the firm by a Chinese business.
Before Alan and Denny go to the Supreme Court, they must fight an injunction to keep them from getting married to each other. Meanwhile, religious differences could threaten Shirley and Carl's upcoming wedding.
