Stimpy's stupidity becomes too much for Ren and he leaves home to become a hermit. All alone, Ren begins to go crazy because he misses his true friend.
Stimpy is becoming dangerously stupid. Ren is injected into his body in a race against time to find the problem./When Ren and Stimpy try to collect money from their paper route, Pierre convinces them to grow up and get a man's job - lumberjacking.
Ren & Stimpy go to the Natural History Museum to see the skeletal remains of the mammoth Stimpysaurus. Wilbur Cobb tells them about the evolution of the great beast and says that even the meat-eating Renosaurus couldn't conquer the huge bumbling idiot.
Renwaldo sends Stimpleton on a food mission to trade their last chigger for some cheese. Stimpy meets a village idiot and trades his chigger for the magical golden singing cheeses.
In a deranged tribute to the "I Love Lucy" show, Stimpy lavishes affection on a store-bought oven-ready chicken. Next, Powdered-Toast Man and Waffle-Woman face off in a fight-to-the-death; the world hangs in the balance.
It's the 11th hour at the dog pound and Ren and Stimpy are about to take that last long walk. A sweet rich old lady falls for them and adopts them immediately.
Ren and Stimpy find themselves in elf and gnome world where everyone happily works to graduate Pixie status. Stimpy loves his new work, but Ren thinks it's too hard and everyone is too happy. Ren decides instead that he wants to become a pixie king.
Ren & Stimpy journey to the Blue-Cheese Mountains to become miners. After dealing with some savages, they finally reach the blessed mountains where they mine the cheese and dream of being rich.
Wilbur Cobb tells a campfire story about Galoot Wranglers. Ren and Stimpy play the part of the galoot wranglers.Ren goes crazy and is sent to a home. Here we see the whole cast of the Ren & Stimpy show has gone nuts.