When the COVID-19 pandemic hits Seattle, the Station 19 crew leans on each other for support; Andy tries to make sense of her mother's return; a group of teenagers unintentionally starts a wild fire.
Andy takes the day off to continue to sort out her family life; Maya and Carina do their best to maintain their relationship while unable to physically see each other due to COVID-19 restrictions; Sullivan strives to work on his sobriety.
The future of Sullivan's career hangs in the balance as his hearing gets underway; the crew investigates an electrical fire at a neglected apartment building that serves as the home for some of Seattle's most prominent drag queens.
The team responds to a difficult domestic dispute involving a pregnant woman. Travis struggles to deal with a family crisis, and Maya and Carina's relationship continues to grow.
Andy and Sullivan find a way to stay connected; Ben confronts a tough loss; Jack and Inara grow closer; while off duty, the crew jumps into action to help a mother in distress, but their heroic efforts spark conflict with police officers.
Carina and DeLuca pursue Opal, the woman suspected of sex trafficking; Maya leaves Andy in charge for the yearly inspection; Dean and Vic struggle to cope with the fallout of Dean's traumatic arrest.
The Station 19 crew is called to a cult gathering where they find their leader dancing on the roof and claiming he can fly; Travis gets a surprise visit from his father; Dean makes a decision that could affect his career trajectory.
Vic's love life is complicated again as she learns of a shocking secret while Andy grows frustrated at Sullivan for undermining her authority. Maya struggles to keep her jealousy at bay when one of Carina's old flames comes to visit.
Vic and Travis' friendship is put to the test as they respond to calls to help two best friends in need; Jack realizes he has a greater impact on Marcus than he thought; new details about Travis' late husband's tragic death are revealed.
Andy, Sullivan, Dean and Ben are faced with a tough choice while trying to save a couple trapped in a car; Carina's immigration status is called into question.
Maya, Jack, Vic, Travis and Sullivan respond to a burn call at an ice rink; a pregnant woman and her husband seek out the station for help; Maya and Carina have a difficult conversation.
Ben finally faces the health issues he has been putting off, Jack and Inara help their neighbor out of a difficult situation. Elsewhere, Carina and Maya reevaluate their relationship.
Maya addresses some unresolved family issues while the crew take matters into their own hands when faced with a life-or-death moment on scene; Andy and Sullivan's marriage is put to the test.
