While on vacation in Vancouver, Shawn finds himself in the presence of an elusive art thief that Lassiter has worked his whole career to catch, much to his ill, and Gus's as well.
Shawn and Gus arrive at the scene of a plane crash in time to find that the pilot wants the duo to avenge his death - and the two proceed to investigate the man's pretentiously wealthy family.
When Lassie's favorite childhood hangout is going to close, he secretly hires Shawn to investigate the reason - and he and Gus uncover a dead body in the process.
After a shootout in a bar, Shawn and Gus learn that a ruthless drug lord is targeting everyone who worked on the one case they weren't assigned to - or is he?
A member of Gus's college singing group is murdered, and while the other surviving members are no longer on speaking terms with Gus, they hire Shawn anyway to investigate the crime, after the police classify the death as accidental.
Juliet hires Gus to track down an old boyfriend, but Shawn eventually finds out that he's in the witness protection program as the key witness to a huge murder case.
A murder in a convenience store leads Shawn and Gus to believe that the victim contracted a deadly experimental virus, seeking not only who's behind it but who may also hold the cure to it.
