Cole gets pulled into a mystery involving an ailing woman from his past and must team up with Agent Catlett in order to recover the stolen money from an old robbery case before the crooks do.
After Westlake kills the partner of an international assassin, she is stalked by the assassin who wants revenge. Meanwhile, the team must determine why the assassin is in town and who their intended target is.
Agent Cole's first big case comes back to haunt him after a man is killed in an explosion and the case resembles the M.O. of a thought-to-be-dead serial killer.
Cole comes to the rescue of his old CIA mentor when he is targeted by a group of assassins over some stolen files, which may expose corruption within the agency.
Cole and Westlake butt heads with a new agent who's part of another, experimental "Viper" program. Meanwhile, Frankie deals with a domestic situation involving William.
As Westlake deals with a visit from her mother, her and Cole get tangled up with an ex Cold War era spy who complicates the team's attempt to recover a stolen satellite system before it is altered to cause mass destruction.
After Westlake's mob informant is murdered, Cole goes undercover as a masseur in order to get close to a group of mob wives, who the team hopes will help bring down the crime families before a turf war breaks out.
As the team tries to bring down a drug ring distributing crystal meth, Cole tries to intervene in the troubled life of his underaged niece, who is learning the hard lessons of drinking and driving.
While Cole and Frankie are stuck at Viper headquarters repairing the Defender, Westlake's wilderness retreat doesn't quite go as planned when two criminals show up in an attempt to extort one of the wealthy participants.
Cole and Westlake race to find an escaped convict who is unknowingly infected with a deadly flu virus before the woman can infect others. Things take a turn for the worse when a hostage situation breaks out.
After an old gangster is murdered, Frankie reminisces about a mob nightclub from his past, as Cole and Westlake try to track down a mobster involved in an old robbery case.
As Cole and Westlake investigate a case involving the Japanese mafia and biological weapons, they are dogged by a sleazy tabloid journalist and end up in the midst of a media mogul couple and their divorce.
After a charity event is robbed of a one million dollar donation, Cole's new girlfriend becomes a suspect in the robbery, while Westlake tries to track down one of the robbers through his ex-wife.
After an attempt on his life, Catlett ends up with a case of amnesia, which causes him to be super-nice to everyone. Tasked with looking after him, Cole and Westlake try to use him to find out who's killing agents.
After someone breaks in to Metro headquarters and uses Catlett's password to try to access information, the team begins investigating who on the inside might be involved, and tries to clear Catlett's name.
Westlake and Catlett go undercover, posing as a husband and wife team of thieves, to bust a powerful crime lord and keep a disk of secrets from going to the highest bidder.
When two criminal brothers try to kill a protected witness, Cole and Westlake look for a disk containing the names and locations of protected witnesses, not realizing it has ended up in the car of a distrusting civil rights lawyer.
Cole returns to the small town where he grew up to investigate the suspicious death of the town's sheriff, who his father is convinced was murdered. Cole's return drudges up some painful revelations about his relationship with his father.
When Westlake's ex arrives in town pursued by armed men, the Viper team is pulled into a case involving an international drug kingpin. Meanwhile, Catlett conducts an audit on the Viper program's spending.
Westlake goes undercover as a corrupt agent to disarm and recover a stolen nuclear bomb, but things take a complicated turn when a rival group steals the weapon and abducts her.
The attempt to steal the Defender results in Thomas Cole being kidnapped by a criminal named Giles Seton. Ignoring that the Viper is the Defender, Seton teams up with Terry Hawkes, a man who looks like Cole in order to carry out the plan to steal the Defender. Cole fails to tell them how to shut off the car's homing device and Hawkes gets greedy. The parting shot is the destruction of the Viper during the final showdown.