Peter is beginning to give up. He's tired of Spider-Man being called a menace when he tries to help. But when he receives a letter from Spidey's #1 fan, Tina, he decides to give Spider-Man one last swing.
After an explosion at Oscorp Industries, Norman Osborn has gone missing. Soon after, a menace called the Green Goblin appears and starts kidnapping the chair members of Oscorp's board.
Robert, a former troublemaker, has been trying to help his mother with her business and her illness. But when a new gang, lead by Big-Wheel, threaten them, Robert takes matters into his own hands.
Alistair Smyth is planning on betraying the Kingpin. But when Kingpin finds out, he hires Landon to inject his mutation formula into Smythe. Now Smythe has become the Ultimate Spider Slayer.
Tombstone, one of Silvermane's former henchmen, has returned and is threatening to ruin the life of childhood pal, Robbie, if he doesn't destroy the story that he's about to print about the Silvermane family.
Baron Mordo is back. He is planning to steal Tony Stark's technology on dimensions so that he can bring the being known as Dormammu to Earth. But he will also need the help of Spider-Man's greatest enemy: Venom.
The Venom symbiote has produced a new symbiote, attaching itself to serial killer Cletus Kasady to give birth to Carnage. As Venom's replacement, Carnage helps Mordo with his plans. Now, Spider-Man must team up with Venom and Iron-Man.
After Tony Stark eliminates Dr. Ohn's research on dimensions, Ohn makes a deal with the Kingpin. After a malfunction in his new lab, Ohn is sucked into another dimension and becomes a powerful being, know as The Spot.
The Hobgoblin returns, this time with the time dilation accelerator. The Kingpin turns to Norman Osborn, who created the Hobgoblin, for help. But when the Green Goblin takes over, it's war.
