Gama and Morris go back to Naco escaping from the American police. They find the town harassed by drug dealers fighting over the plaza. Unable to locate Wendy, they decide to go back to the US, running away from El Dragon's revenge.
While the quarrel between El Dragón and Natividad continues, Gama and Morris try to save Wendy before it's too late. A mysterious migrant arrives to the coyotes' hideout. No one suspects that it's actually a ghost.
Three young filmmakers arrive at Naco to shoot a documentary on crossing the border and end up stuck in the middle of the drug traffickers' quarrel over the plaza. The filmmakers will resort to Gama and Morris to escape from that hell.
Naco's children baseball team has to cross over to the USA to compete in the final match against a gringo team. Without visas or resources whatsoever, they will have to trust Gama and Morris' wit to make it on time for the game.
An Argentinian couple arrives at Naco to develop a mega infrastructure project that will turn the town into the future Mexican Dubai. Gama and Morris don't think it twice before joining the venture without measuring the consequences.
At the border, migrant's children are separated from their parents due to new regulations of the American government. Overwhelmed by the dramatic situation, an American soldier of Hispanic origins turns to Gama and Morris for help.
A young gay man escapes from his family's oppression and makes it to the border looking to cross over to the United States. Gama and Morris will accompany him to San Francisco where he will find a new love.
Tisha, an old acquaintance of Gama and Morris, contacts the coyotes once more to cross her dead grandpa to the other side of the wall. This time things will not work out as she expected.
A pregnant woman with a womb for rent flees the US to avoid separating herself from the soon-to-be-born baby. The delivery takes place at Naco and when Gama and Morris try to convince her to give the baby back to his lawful parents.
Lupe and Kewewe get married and, since they have a client that has to make it to Miami, the whole coyotes' band decides to go with them to Disney World for their honeymoon.
Güevín goes missing. Gama, Morris and their friends desperately look for him fearing a new revenge from Natividad. No one suspects that Güevín has actually been abducted by an alien spaceship.
A film crew arrives at Naco to shoot a film about Güevín's extraterrestrial adventures. Dolores Harrison, a celebrity and the star of the movie, will be left under the coyotes' watch whose job is to look after her.
The Apocalypse is coming. The only place safe left on Earth is the Sonora border, where Naco is located. It doesn't take long before there is a massive exodus of gringos to Mexico. Fake news or reality. The world is upside down.