Rome Empire looks at the increasingly deranged and paranoid reign of Emperor Caligula. He a kills his heir and forces his praetorian prefect to commit suicide. In search of a new heir to solidify his place as Emperor, Caligula begins affairs with his three sisters in order to have a child of royal blood. When his sister Drusilla dies, Caligula becomes deranged and the plot of three daggers surrounds him.