Minus Penhall, the team returns to 21 Jump Street after the summer. Working with Booker, a new officer, Hanson investigates a vandalization incident that appears to be a hate crime.
The team works a case involving drug dealers while keeping an eye on The Rangers, a group of civilians that patrol the street to prevent and solve crime.
Hoffs goes undercover at a school that has a clinic that gives teens information about birth control. Ioki works undercover within a group protesting the clinic's presence on campus. Booker sets up Sal on a date.
Investigating a rape on a college campus, Hanson, Ioki and Booker go undercover in two fraternities. Hoffs goes undercover in a sorority and Penhall in a dorm.
Rejecting the city's contract renewal offer The Association of Municipal Police Officers goes on strike. As management, Captain Fuller must continue to work. Hanson observes the union negotiation and the rest of the team strikes.
Penhall investigates a group of nerd students that break into the school computer to change grades. Since he's blending in with the nerds, he's being bullied. The team exchanges bully stories.
Booker goes undercover within a group of drug using and dealing teens, but when the gang suspects that one of their own is a narc, Booker begins to crack under the pressure.
Hanson is suspected of killing a crooked cop who was responsible for Ioki's shooting. He goes on the run. Fuller gets Booker assigned to the cops's partner who might also be crooked, and Booker investigates the shooting. Hanson eventually turns to Penhall for help. Hanson is eventually caught and placed on trial.