Nancy goes on vacation to Miami, where she encounters a lot of bans from the resort manager. Suddenly, Polly arrives there to rest and helps her solve problems, after which they begin to spend time together.
After cheating on an eye test, Jesse is forced to wear glasses and endure ridicule from his classmates. Meanwhile, Nancy competes with Charlie for the title of best class 402 athlete.
The school shows an educational film about where babies come from, but Jesse misses everything because of his mother. Polly opens a repair hospital for spoons.
On Halloween, the school hosts a masquerade party. Jessie and Vinnie teach curses to Mr. Besser's parrot, and accidentally give their names. After learning that Panny wants to dress up in Little Bo-Peep, Nancy looks for the same costume.
Jesse is sent to live with his grandparents while his parents are away. Vinnie is serving his sentence in the Principal's office for a prank he and Jesse pulled the day before.
The class is going to summer camp. Arthur is embarrassed to change in front of other children. Nancy wants a badge for survival in the wild and is going to spend the night in the forest with Penny and Polly.
In class 402, a new student Melanie appears - the daughter of Miss Bellanchof, who has a bad temper. Nancy begins to identify with the new incarnation of an Indian princess.
Nancy and her classmates undertake to grow plants for the school competition, but almost immediately flies away to rest in Miami with her grandmother, leaving the garden to her friends.
Melanie's mother constantly punishes her, so she begins to send herself invitations to her classmates' holidays to go out for a walk. Vinnie drew a picture that looked like a woman's breasts, which caused Miss Graves' indignation.
Nancy is diagnosed with asthma. Secretly from her mother, she refuses conventional treatment and relies on the methods of Dr. Dedorio, who promises a quick recovery.
Melanie wants other girls to be friends with her. Therefore, she decides to quarrel between them with the help of a Slam book, where everyone can write what they think about others.
Nancy and the other girls dress up like a famous singer. Mr. Besser is annoyed by this and introduces a school uniform. Jessie and Vinnie plan to get their ears pierced.
Miss Graves has a nervous breakdown due to the endless chatter of the nurse, whom she agreed to give her regular rides to school. Meanwhile, Nancy and the girls are frightened by mystical stories about a new student.
