In the wake of an unexpected betrayal, the Sanctuary must pull together to figure out the Cabal's master scheme in time to save those closest to them and the whole world.
The Cabal's new "Super-Abnormals" begin destroying Sanctuaries around the world. It won't be long before they launch their attack on the Old City Sanctuary, and Magnus must choose between saving Ashley and saving the Sanctuary Network.
Kate accidentally sets loose a baby Abnormal that she and Henry discover grows very quickly. Meanwhile, Magnus searches desperately for a way to bring back Ashley.
The Sanctuary team hunts down a man who seems to have superpowers, calling himself "The Adjuster." But they discover that his suit is the source of his power, and it is slowly killing him. But he can't get it off.
When Dr. Magnus awakes to darkness, she must face a destroyed Sanctuary, city, and even world. But beneath the apocalypse, something deeper awaits her discovery if she can find it in time.
A research scientist working for the Sanctuary Network is brutally attacked by an abnormal. While Helen Magnus tries to save the life of the scientist, the team investigates the origin of the attacker's uncharacteristically brutal behavior.
When Bigfoot is discovered dead, all of the evidence points to Magnus. Will, Henry, and Kate must find a way to clear her name and find out who actually committed the crime before she is replaced.
While transporting a usually docile abnormal, Magnus's helicopter crashes, leaving her and Will stranded in the shaft of an abandoned oil rig. They soon find they are not alone in the water.
While an old friend of Magnus', a pouched abnormal named Jimmy, is handing over a fire elemental to the Sanctuary team, they are attacked by a gang of criminal abnormals from Chicago. The situation presents a lot of mysteries to be solved and quickly.
When rich youngsters begin to disappear after an apparent death and then come back to life, the trail leads Will & Magnus to a drug clinic in Mexico run by Nicola Tesla. Knowing his all-times plans, big trouble to be expected.
When a ship full of Zulu empaths suddenly goes to wreck, John Duitt rescues them as a favor to Magnus. However a bitter discovery awaits her: his dark side is alive again and can even have a life of its own!
After peaceful Abnormals worldwide act up at the same moment, the incident is linked to an EM pulse originating in Mumbai. Will and Kate go to investigate, and they soon discover that the event may relate to a dangerously-powerful Abnormal.
