John and Luke investigate Jac Naylor, a registrar from Holby City Hospital who is suspected of killing a patient; Luke becomes a father; and Kate and John meet the new DCI.
When John goes to see his father in prison, the visit rakes up the past and irrevocably changes John's relationship with Kate. Neil finally tells Kelly how he feels.
While the girls go off on a night out, John and Luke investigate a series of smash and grabs; and William has an unfortunate encounter with his mother.
A grieving Luke and an angry John are at loggerheads over a case involving John's dad. Christian's relationship with Miranda progresses, and Lucy and Jake take on a case with dire consequences.
The station is thrown into panic as a sniper shoots at Holby South Police cars. John's dad brings Kate and John's relationship to boiling point and Kelly finds out about Roger.