Ralph sells self-help, "how to be successful books" which brings good fortune to everyone who reads it. John is skeptical of its worth and has to decide whether to read it or not.
Louise informs the group that her family which consists of her parents and sister are coming to see her and her baby. But she didn't tell them that she's a single mother and they are coming to see her husband. So she asks if one of them could pretend to be her husband. They refuse. But later each of the guys shows up and they each meet one of her family and the one who meets who comes thinks that he is Louise's husband. So she tries to keep them apart.
John learns that Mike, the guy his wife left him for is having an affair. He feels like a big man and lets Mike know he knows. But Mike knows he's not going to tell his ex because he still cares about her. And John feels like a wimp.
John's uncle Jack passes away. John promised his uncle that he'd look after aunt Emma (Jack's wife) if he died. So Emma comes to stay with John and makes life miserable for John by laying guilt trip after guilt trip on him. She is ungrateful and nothing John or anyone for that matter does is good enough. One day she comes (uninvited) to the One Two One group and makes life hell for all the members. They want her gone from the group and tell John to tell Emma as much. John wants her gone also, but can't tell her because of his promise to his uncle. He finally decides enough is enough and goes to tell Emma. How does she react?
Kate dates a man she finds attractive, but he decides to move on and not see her again. She finds out why and then understands. He has a terminal illness and he wants to see the world during his remaining days.
Mrs. Philbert decides to attend her high school reunion, but Tom won't be able to take her. John tries helping out but old high school rivalries make John wish he had stayed at home.
During Kirk's attempt to seduce newcomer to the group Mary Beth, Mary Beth becomes the aggressor, but Kirk is unable to perform. Kirk then develops anxiety about rejoining the group for fear that Mary Beth will reveal his impotence.
Kirk invites John to accompany him on a ski trip for two that Kirk has won. John encounters a man with whom he connects and spends all his time on the trip with that man while ignoring Kirk.
The group members panic and the group becomes dysfunctional when new attendee Lionel announces that he has been in prison for the murder of an IRS agent.
Despite the good salary and rewards of being an editor for a publisher, John has misgivings about his new job because his former admiring female student who hired him expects romantic reciprocation.
Louise reluctantly agrees to let John watch her baby, so Kate and Mary Beth can treat her for her birthday. John along with Kirk and Ralph go to get Louise a baby portrait at a photo study where the baby is switched.
John skips the group meeting persuaded that he has become too dependent on it by the coach who wants him to join a poker game. In John's absence, the group debates whether the group is an addictive force curbing their progress.
The support group prepares a birthday party for Kirk only to realize that he might be lying to them about the day of his birth. Kirk decides to come clean when his secret wife from India shows up. Or does he?
Angry at his uncaring father, Red's troubled teenage nephew Danny visits her and asks to stay with her. The support group offers help, so he stays with some of them. However, he connects only with Kirk, whose bad influence worries Red.
A divorce lawyer joins the group as a new member. He convinces Kate and John to sue their exes who are exploiting them. Hyped by this, John even decides to help his students cheat on a test in order to win the teacher of the year award.
