Everyone has plans for Thanksgiving: Ira and Jeff go camping, Rachel's bound for Boston, Maryann expects a visit from Justin, Zoey makes plans with Sean, and Cybill is forced to work with a tyrannical prepubescent costar.
Cybill decides to resume dating David, but Maryann becomes convinced he murdered his wife. Meanwhile, Zoey enlists Rachel to accompany her on a Mexican road trip to secretly repair Cybill's car.
Zoey rebels by vanishing, sending Cybill and Maryann on a wild goose chase to find her. Meanwhile, Ira tries to pass off a prostitute as his new love interest, and Cybill stars in a corny superhero show.
Cybill opens up her home to an eccentric old Hollywood actress; Zoey discovers the guy she's been cyber-taunting is Kevin; Ira works as a garbage man to research his latest novel; Maryann schemes to destroy Dr. Dick's new marriage.
Convinced that Kevin is having an affair, Rachel contemplates cheating on him with her mechanic. Cybill and Maryann arrive at the motel in time to prevent a disastrous misunderstanding - Kevin is actually distracted by his failure to gain tenure - but discover Sean, Zoey's boyfriend, getting ice for the girl he's cheating with. Kevin and Rachel agree to work on saving their relationship; Zoey tells Sean to get out of her life.
Cybill begins experiencing pre-menopausal symptoms. Meanwhile Ira's mother comes to visit and he soon realizes she's become a different person; and a horse wanders into Cybill's back yard.
Following her breakup, Zoey bonds with Cybill. Meanwhile, Maryann tries to make Ira jealous by leading him to believe she's having a fling with Cybill's visiting redneck cousin Lyle.
Cybill gets a job as a clown on The Major Milo Show and has to fend off the advances of the star. Meanwhile Zoey graduates, Rachel tries to relive her childhood and Maryann and Ira attempt to have sex.