After succeeding in his goal to conquer the world, Dr. Gangreen attains inner peace and releases the Tomato Task Force from his dungeon, which leads to his own creations turning on him.
Dr. Gangreen is missing and the KTTF splits up to find him. Tara travels to Paris, France to locate him but only manages to locate the Phantomato of the Opera. Is he friend or foe?
Will the Killer Tomato Task Force join Gangreen and Igor in an uneasy alliance to combat their mutual enemies? And is the key to defeating the tomatoes located in the heart of Africa, where they can't seem to get a clear foothold upon?
Travelling to Africa, Chad, Tara, Dr. Gangreen and Igor locate the one enemy that can defeat the tomatoes, the African Tomato Worm Tribe. Can they arrive back in San Zucchini to save the KTTF in what may be their last stand?
Gangreen begins his new plot to take over the world with a new creation named the Ultimato, armed with a brain cloned from the angry Doctor himself. They deceive the KTTF into thinking it's on their side but the creature has its own plans.
The KTTF and Gang of Six trade places which leads to the newly-tomatoed Wilbur and his team being on the run while the now-human Gang of Six plan on putting the African Tomato Worms on ice.
With humanity reclaiming Earth from the Killer Tomatoes, Fang stages an uprising and ousts Zoltan from the Gang of Six. Zoltan forms a alliance once more with Dr. Gangreen, who creates five new tomatoes to fight against Fang's crew.
