CDC may be dealing with a potential deadly virus outbreak in Las Vegas, and Sara and Greg may have been exposed to the virus while investigating a crime scene.
An ex-con buried alive in the desert is killed after being hit by a car. The CSI investigation takes them into the world of pool, high-stakes hustling, and prostitution.
Sara reopens a 10-year-old family murder/suicide case when the lone surviving daughter claims to have a new memory about that fateful evening that proves that the father didn't do it.
A final showdown between the CSIs and the Gig Harbor Killer, whose motives are revealed. Meanwhile, Nick Stokes makes a decision that affects the team moving forward.