After Bright Eyes was unable to be adopted at Adoption Day, a mysterious man by the name of Sam Quintinn arrives at Holly's puppy pound and views her as a star.
The Pound Puppies tell their story of how Holly became the owner of a puppy pound and how they came face-to-face with the villainous Katrina Stoneheart for the very first time.
The Pound Puppies and Holly meet Buster, a puppy who is "a walking natural disaster". They are later invited to the Bellveshires' mansion in hopes of saving the pound from Katrina Stoneheart's latest dastardly plot.
The Pound Puppies rescue a pregnant dog from a severe snowstorm. However, when the power gets knocked out, it's up to Cooler, Howler, and Whopper to find a nearby veterinarian while the girls tend to the soon-to-be mother.
After wishing upon a star, The Pound Puppies meet an oddball fairy dog mother named Zazu, in hopes of helping Holly win the heart of a young boy named Mervin.
When Whopper's uncle JR comes for a visit, the Pound Puppies and Holly disguise themselves as a wealthy family in order to impress him. However, Uncle JR has a secret of his own.
Accusations fly when the Pound Puppies' beloved items were stolen. To make matters worse, if one of them is found guilty of stealing, he or she will be banished from the Pound forever.
While in pursuit of rescuing Whopper from the evil Captain Slaughter, the Pound Puppies and Holly meet a trio of strange cats who wanted Captain Slaughter to capture them. But why?
After Bright Eyes is kidnapped by two foreign spies, the other Pound Puppies, along with Pupnik, a friendly puppy from Mongrelia, go on an adventure to save Bright Eyes, James Bond style.
Cooler meets his long-lost girlfriend, Penelope, but is still angry with her. Why is Cooler heartbroken? It all had something to do with Captain Slaughter and the once-existed town of Wagga Wagga.
A trio of dogs, known as the Three Wise Guys, are looking for a legendary canine called the Star Puppy and Nose Marie was selected. Meanwhile, Captain Slaughter is also looking the Star Puppy and aims to make a fur coat out of Nose Marie!
Holly's Puppy Pound finally, and unfortunately, closes down no thanks to Katrina Stoneheart, Brattina, and Catgut. With no hope in sight, only a Christmas Miracle will once again open Holly's Puppy Pound.
When the Terrible Terrier haunts Holly's Puppy Pound, the Pound Puppies turn to Biff Barker, a famous dog actor from a well-known TV series, "Ghost Hounders", for help.
