Black Jack is given a chance to redeem his medical license, by treating the son of Detective Takasugi who has Paget's Disease. The operation is a success, but Black Jack is arrested.
Black Jack's father begs Black Jack to perform plastic surgery on his new wife's face and Black Jack decides to make her new face his mother's. After he returns, a bomb detonates seemingly killing him.
Pinoko refuses to believe the doctor has died and for a while lives with Tetsu and then a family that runs a local hospital before meeting up with him and going to Europe.
Black Jack and Pinoko go to Europe to track down Dr. Kreutzer but learn he is comatose and Black Jack must pretend to be him to perform surgery on the mother of a young girl he befriends.
Black Jack goes to meet Dr. Stein, a major leading expert on prosthetic limbs and organ transplants who refuses to see Black Jack for fear of the organization killing him. On the way, Black Jack also meets an old acquaintance.
Sky Hospital has landed in a small Middle Eastern country. Pinoko and Black Jack stops in a restaurant where they meet a Japanese man who works for a European medical company.
Black Jack and Pinoko reach England by hiding in a box on a cargo ship. Soon after their arrival, they are attacked by Benitokage but they manage to escape.
BJ and Pinoko arrive at Lake Rage in Canada to meet Dr. Joruju. As they walk up to his lakeside cottage, Joruju's daughter (Yuri) fires her rifle at them.
Black Jack and Pinoko arrive into Okonja Village on a helicopter. However, many villagers have already died from various diseases. Black Jack persuades the reluctant pilot to fly further.
Black Jack and Pinoko arrive in Macao. He leaves Pinoko in the hotel room and heads to Kagemitsu's mansion on his own. Renka greets Black Jack and introduces her daughter, Shoren.
Black Jack and Pinoko wait at the departure gate when the airport security ask them to follow. They were led to the Sky Hospital where Dr. Shirabyoshi and Dr. Nishikawa were waiting.
