In the far reaches of the milkyway, on a planet called Zi, there are powerful machines with superior fighting skills called Zoids.

Zoids are beast-like fighting machines used in both everyday use such as transportation, and special use such as war. Some types of Zoids, know as Organoids, are miniature Zoids that are living organisms. These Organoids have the capability to fuse with a non-living Zoid and make it much more powerful. Van (Ban) Freiheit discovers a Zoid Organoid in an abandoned laboratory while running from two strangers piloting Zoids. Also in the laboratory, in an animated suspension tube is a strange girl. He breaks the tube open and takes her and the Organoid with him. Spotting a ruined Shield Liger Zoid outside nearby, the Organoid fuses with it and repairs the damages. Making his escape, Van names the Organoid Zeke, and decides to keep him as a friend. The girl, who says her name is Fiona, wants to find something called Zoids Eve, and so Van, Zeke, and Fiona begin their adventure.—AniDB

In the far reaches of the Milky Way, on the Planet Zi, there exists metallic life forms that posses superior fighting skills. These are the Zoids. Warriors by nature, Zoids have been used as the ultimate weapons in an ongoing war between the Imperial forces, and the Republicans of Planet Zi. A young boy named Van, born and raised on Zi, holds a strong fascination with Zoids. He develops a special friendship with a Zoid called Zeke, who is able to fuse with another Zoid, thereby enhancing its fighting ability. He also meets a girl called Fiona with whom he starts a journey of discovery to find out about her mysterious past.—Nun Yabez Ness