Masane's fate is altered after uniting with the Witchblade, an ancient weapon that penetrates the body and mind. Forced into the service of the Doji Group and hunted by the NSWF, Masane's greatest battle will be for her soul.

Masane Amaha exists on society's fringe, with no memory and no direction. Upon her arrival back in Tokyo, her fate is altered forever when she unites with the Witchblade-an ancient weapon of ecstasy, power, and pain that penetrates the body and soul. Conscripted into the service of the Doji Group and hunted down by the NSWF, Masane's greatest battle will be for her very soul.—Crunchyroll

Amaha Masane and her daughter Rihoko are on the run from a government child welfare agency that wants to take Rihoko away from her mother. They are caught and Rihoko is taken away. Meanwhile, Masane is attacked by an advanced weapon that can disguise itself as a human being. When faced with the danger, a strange light emits from her wrist and she transforms into a powerful being. She destroys the weapon and consequently becomes involved in a struggle between unscrupulous organizations, with her at the center of their attention, because she wields the legendary Witchblade.—AniDB