A brilliant gambler lays down his life as the wager for various games against dangerous opponents.

There are gamblers out there who even bet their lives as ante. But to secure the integrity of these life-threatening gambles, a violent and powerful organization by the name of Kagerou referees these games as a neutral party. Follow Baku Madarame a.k.a. Usogui (The Lie Eater) as he gambles against maniacal opponents at games such as Escape the Abandoned Building, Old Maid, and Hangman, to ultimately "outgamble" and control the neutral organization of Kagerou itself.