When a group of hunters genetically modify Graboid eggs, they face an all-out war against the larger, terrifyingly intelligent Graboids, and the swiftly multiplying Shriekers.

When a nature preserve in the Solomon Islands is infiltrated by Graboids, Ass Blasters, and Shriekers, two of the preserve's top scientists recruit Burt Gummer, monster hunter extraordinaire, to eradicate the infestation. While there, Burt picks up a potential new protege and encounters lost love.