After wrecking their house during a chase, Tom and Jerry enter a race around the world where the winner gets a new fancy house.

Tom and Jerry and other racers try to win the key to the prize. First they go to Mexico and find out that the ratings are too high, so they extended it to the Amazon Jungle. Tom eliminates a soccer mom by making her drive her minivan into a pit of quicksand. Bugs swarms and eat the soccer mom.