Tiku, who looks at marriage as her escape to Mumbai from a local town to become an actress and Sheru, who has been working as a junior artist in the city for years. They get married and the comedy of errors for this couple starts.

Tiku Weds Sheru is a romantic-comedy about two quirky characters who dream of becoming film stars. While their romance blooms, they get caught between the chaos of the underworld, drugs, and face one tragedy after the other. Will their relationship survive the odds thrown at them?