In 1943, Albert Hofmann discovered LSD. Fractions of a milligram are enough to turn our framework of time and space upside down. The story of a drug - its discovery in the Basel chemistry lab, the first experiments by Albert Hofmann on himself, the 1950s experiments of the psychiatrists, the consciousness researchers, the artists. Could it actually be possible to find a path to the core of our human existence by means of a chemical? Spirituality at the flick of a switch? Do the enigmatic effects of this drug really help us to better understand the human soul? Could LSD be an instrument of contemporary psychiatry? Of modern brain research?—Martin Witz

By coincidence rather than by design, the Swiss chemist Albert Hofmann makes a sensational discovery in the spring of 1943. He realizes that he is dealing with a powerful molecule that will impact not only the scientific world. The Substance is an investigation into our troubled relationship with LSD, told from its beginnings until today.