Two mice of the Rescue Aid Society search for a little girl kidnapped by unscrupulous treasure hunters.
When a bottle containing a plea for help from a little girl named Penny makes its way to the Rescue Aid Society, a mouse organization in the basement of the United Nations building dedicated to the rescue and well-being of anyone in need, it is up to the brave mouse Miss Bianca and her chosen partner, the shy janitor Bernard, to rescue the girl. Searching for clues at Penny's home at Morningside Orphanage in New York City, the two mice discover that the girl has been kidnapped by the evil pawn shop owner Madame Medusa and her companion Mr. Snoops. On the back of Orville the albatross, Miss Bianca and Bernard travel to the terrifyingly gloomy Devil's Bayou where they learn the shocking truth: the innocent young girl is being forced down into a dangerous, dark underground pirate's cave where she must find the Devil's Eye, the world's largest diamond and Madame Medusa's greatest obsession. Before returning safely home, Miss Bianca, Bernard, and Penny will have to combat Madame Medusa's two ferocious pet alligators Brutus and Nero with the help of Ellie Mae and Evinrude the dragonfly, as well as survive the raging tides inside the horrible pirate's cave.—Frederick Irizarry
When a little girl named Penny sends a bottle containing a written plea for help, Miss Bianaca, a Rescue Aid Society member and a representative of Hungary embarks on a mission with her new partner, Bernard, who is a janitor and dreams of being a member of the Rescue Aid Society. The two head to Morningside Orphanage to get some clues regarding Penny's disappearance. An elderly cat named Rufus reveals to Bianca and Bernard that Penny ran away and she was captured by a strange woman who is running a pawn shop. Bianca and Bernard go to Devil's Bayou in Louisiana to rescue Penny from Madame Medusa, who wants a priceless diamond that is worth millions of dollars. Along the way, Miss Bianca and Bernard get help from Ellie Mae, Luke, and the swamp folks on saving Penny from the greedy Madame Medusa and her incompetent sidekick Mr. Snoops.—dawsonpersi
Bernard and Bianca, of the Rescue Aid Society (a mouse organization) receive a message in a bottle from an orphaned girl who appears to have been kidnapped by Madame Medusa, a selfish woman who has no qualms about using children for her own purposes. The two mice go off to Devil's Bayou to attempt to rescue the little girl.—Tim Pickett <[email protected]>
A bottle containing a plea for help arrives at the Rescue Aid Society, an organization of mice from all over the world whose mission is to help those in need. Bernard and Miss Bianca are chosen for the task and after gathering the needed clues and information, they fly on the back of albatross Orville to the gloomy and uncharted Devil's Bayou. There, together with Ellie Mae and other swamp folk, they must work together to save a little orphan girl from the evil Madame Medusa.—Frederick Irizarry
The story begins in a swampy bayou, where a little girl is seen on an abandoned riverboat, dropping a bottle over the side of the boat. The bottle is the carried away by the waters, and after some time, arrives along the shores of New York City, where several mice find it.
The bottle is then brought before the International Rescue Aid Society, an organization of mice that gathers inside a luxury suitcase in the basement of the United Nations building. Inside is a note that is recovered by a janitorial mouse named Mr Bernard. Once the note is retrieved, the Chairman and the Hungarian representative named Miss Bianca then read over the message:
"To Morning Side Orphanage, New York
I am in terrible trouble. Please hurry. Help!
Penny."
Miss Bianca volunteers to help the little girl, and the Chairman allows her to choose any of the delegates to assist her. To their surprise, Bianca chooses the janitor, Bernard.
Taking a clue from the letter, they head to the Morning Side Orphanage. In a closet, they find a box with Penny's name on it, along with her belongings inside of it. As they ponder what has become of Penny, they are interrupted by Rufus, a friendly old cat who lives in the orphanage.
Bernard interviews Rufus for clues regarding Penny. Rufus explains that before she disappeared, Penny eagerly wished to be adopted and find a loving home. However, with little information to go on, the Police have stopped looking for her.
When Bernard asks if the old cat might have more information, Rufus mentions a "trashy lady" who offered Penny a ride in her car. The woman and her partner run a pawn shop down the street from the orphanage, and Bernard and Bianca head off to investigate.
The two mice soon find themselves at Madame Medusa's Pawn Shop, and come across a writing book with Penny's name in it. However, they hide quickly when Medusa appears to answer a phone call.
As they listen, Medusa berates a person on the other end of the phone named Snoops, for not having found a diamond after three months, and finding out Penny has been sending messages in bottles. The angry woman tells Snoops she is heading down to the Devil's Bayou immediately, and Bernard and Bianca tag along in her suitcase. However, Medusa's erratic driving causes the luggage to spill out on the sidewalk, leaving them unable to follow her directly.
The two mice then pack quickly, and make their way to a rooftop skyscraper, to catch a flight to the Devil's Bayoul via Albatross Airlines. The flight is conducted by an albatross named Orville, and after a harried take-off, the two mice are on their way.
As they reach the bayou, Orville finds himself dodging fireworks being set off by Medusa's partner, Mr Snoops, in his attempt to light up the bayou to help Medusa and her pet alligators (Nero and Brutus) find Penny, who has run away again.
As Orville and the two mice come down into the swamp, they encounter a couple of muskrats named Luke and Ellie Mae. While Orville is grounded due to his tail feathers having caught fire, Ellie Mae supplies the mice with a dragonfly named Evinrude, who helps power them through the swamp on a leaf. They eventually find that Medusa's alligators have caught Penny, and returned her to the riverboat.
Medusa eventually returns, and chastises Snoops for his incompetence. She also lectures him again on their plan. In a nearby underground cavern, there is word that a large diamond known as The Devil's Eye resides. However, the hole that leads to it is very small, and Penny was kidnapped because she could fit and retrieve the diamond. However, Snoops is unwilling to get results, and Medusa claims she is going to make sure Penny retrieves the diamond the next day.
Unfortunately, Nero and Brutus smell Ms Bianca's perfume, and attempt to catch the two mice. When Medusa sees the two mice, she panics and begins to blast them with a shotgun.
The two mice eventually get to Penny, and assure her they want to help her escape. Bernard calls on Evinrude to alert Ellie Mae and Jake to help them, but the dragonfly gets held up by some sinister bats.
Because of this, Penny is dragged to the cave the next day, and forced by Medusa to get the diamond. With Bernard and Bianca's help, Penny finds the Devil's Eye, stuck inside a skull. A sinkhole in the cavern soon begins to fill with water, but Medusa refuses to let Penny out.
Using a sword, Penny retrieves the diamond (along with Bernard and Ms Bianca), and is pulled up. Medusa grabs the diamond and drags Penny back to the riverboat. Meanwhile, Evinrude finally reaches Ellie Mae and Luke, and they, along with other swamp critters, head off to the rescue.
Medusa has Penny and Snoops at gunpoint, intending to leave them stranded while she takes the diamond, hidden in Penny's teddy bear. The animals arrive and attack Medusa, while Bernard and Miss Bianca trap Nero and Brutus in the boat's old elevator, using Bianca's perfume as bait. Penny (with Teddy and the diamond) and the others escape on Medusa's swamp-mobile, using Luke's "swamp juice" as fuel. Medusa clings on to the swamp-mobile, but she crashes into the riverboat's chimney and is left behind, bemoaning the loss of her diamond.
Back at RAS headquarters, the delegates watch a TV report on Penny returning to the orphanage, where she has finally been adopted. Penny tells the reporter about how she was helped by mice and greets Bernard and Bianca at the camera, to the reporter's confusion. Just then, Evinrude arrives to report that someone else is in trouble. Bianca once again volunteers herself and Bernard to the new mission, and off they go on another adventure.