During the early Christian era, Karma, a very spiritual and virtuous High Priest of the Temple of India, resists with all his religious fervor, Quinetrea, a beautiful and fascinating enchantress. Quinetrea eventually conquers and Karma falls a victim to her wiles. She triumphantly taunts him, and outraged at her cruel deception. Karma curses her, and Quinetrea is transformed into a huge snake. Fifteen hundred years later, Karma appears, reincarnated in the personality of Leslie Adams and loves the beautiful heiress, Lillian White. Together they visit the ancient Temple of Karma and are shown the reptile, which every hundred years resumes human form. While Leslie gazes fascinated, the snake uncoils and Quinetrea stands before him in all her bewitching charm. She holds him with her hypnotic power and forces him to accept an amulet for his betrothed, upon receiving which Lillian falls dead. Karma beholds a vision of his former self as High Priest, again curses Quinetrea, and drops dead across the prostrate body of his betrothed.—Moving Picture World synopsis

In India, Leslie Adams dreams of a priestess who is turned into a snake by Karma, the high priest. While touring a ruined temple, he finds the snake, who is said to resume human form every 100 years. Assuming her human form, Qunitreea give Leslie's fiancée an amulet, causing her to fall into a permanent sleep. Leslie realizes he is the high priest Karma reincarnated, and that Qunitreea has had her revenge.—David Eickemeyer