Betrayed by Spanish conqueror Pedro de Heredia after their romance, indigenous woman Catalina returns 18 years later seeking vengeance, determined to end Pedro's life as he ended hers by making her fall for him.

This is the story of Catalina, the indigenous woman who gave away her soul, her heart and her life to a conqueror. "The Queen and the Conqueror" rebuilds one of the first love stories that took place in America, between an indigenous woman and a Spaniard. After establishing the city of Cartagena, Pedro de Heredia, motivated by the need to save his brother, betrays Catalina. Heartbroken, she escapes, only to come back 18 years later, as a grown woman. In her soul, her only mission is: revenge. To end Pedro de Heredia's life, the same way that he, after making her fall for him, ended hers.