Merv Griffin invites a series of actors, actresses, writers, and directors to discuss the progressive work they have done and current culture, arts, and entertainment surrounding the numerous projects.

Merv Griffin interviews actors, actresses, writers, authors, directors, scientists, doctors, psychics, politicians, etc. to discuss their past and current work; the current pop culture; the arts and entertainment industry; world events; and medical advice and helpful hints for the viewers at home.