LAPD homicide detective Sal LaBarbera and a team of master codebreakers use their unrivaled expertise to bring the most mysterious serial killer in American history into the light.

Throughout the early 1960s and 1970s, the Zodiac Killer, one of history's most famous unidentified serial murderers, terrorized America in a spree of heinous attacks, sending taunting letters and codes filled with bizarre and ancient symbols. This code has baffled some of the greatest minds in cryptology for over 50 years. "The Hunt For The Zodiac Killer" opens up a new investigation into the mystery of this twisted serial assassin. A team of top investigators and code-breakers, working in tandem with a super-computer, known as CARMEL, the first of its kind programmed to think like a killer. This team believes they may have broken a significant portion of the diabolically complicated code, Z340, and have been granted unprecedented access to police files, new witnesses, new clues, and the cooperation of representatives of the CIA and FBI.