When a nobleman is threatened by a family curse on his newly inherited estate, Sherlock Holmes is hired to investigate.

All who have read the celebrated novel remember the Great Dane that terrorized the superstitious community surrounding the home of the Earl of Baskerville. The death of Sir Charles of Baskerville was connected by the tenantry with the reported appearance of the dreaded hound. Subsequent to the Earl's death, his nephew, Henry, fell heir to the estate. He was notified by the attorney to come to Baskerville but received a warning from another source to remain away. Despite the warning, Sir Henry goes to the manor where he meets Mr. Stapleton, the caretaker. He also learns of his uncle's animosity against Roger, another nephew who was disinherited. Following his coming, Sir Henry soon has cause to fear the hound. He sends an urgent sail to Sherlock Holmes, a great detective. The call is intercepted by Stapleton, who impersonates Holmes. The real Holmes learns of the interloper and goes to Baskerville to investigate. A series of remarkable and terrifying events follow, which almost result in the death of Holmes as well as the Earl and his entire household. Even Miss Lyons, Sir Henry's charming neighbor, nearly becomes a victim of the evil genius who is plotting the ruin of Baskerville. After a harrowing experience, the detective succeeds in killing the monstrous hound. Holmes doubles his efforts to unravel the dreadful mystery and enlists the aid of Barrymore, a discharged servant. Barrymore informs Holmes that Stapleton is the author of all the deviltry. The detective lays a trap for Stapleton, who unwittingly falls into it. After a terrific struggle he is overcome by Holmes and Barrymore. Not until his confession is it discovered that Stapleton is in realty the disgraced nephew, Roger, who, for revenge, planned the destruction of Sir Henry in a desperate endeavor to gain control of the Baskerville estate.—Moving Picture World synopsis