A young boy, who happens to be a genius, lives in a small town with his family and friends and often gets into crazy adventures with them involving the things he invents.

Follows James Isaac "Jimmy" Neutron (Debi Derryberry), his faithful robotic dog, Goddard (Frank Welker), and his eclectic friends and family as they experience life in Retroville. Jimmy is a typical kid, who just happens to be a genius. He creates gadgets to improve his everyday life, but his inventions go awry more often than not, and hilarious trouble ensues.