After the events of Spiders (2000), a scientist conducts genetic tests, and a couple becomes the perfect host. Now, the hunt is on, as an army of arachnids is after the succulent human flesh. Who can stop the spiders' feeding frenzy?

Jason and Alexandra 'Alex', a close couple, lose their sail yacht in a storm and are grateful to get picked up by Captain Jim Bigelow's commercial carrier. Suspicious about the rough treatment and injections given by ship's doctor Gerbac which make the strong man faint, and realizing the ship is improbably empty and the radio not broken as the crew claims, Jason starts snooping around and finds human bodies on meat hooks, but even Alex thinks he's just hallucinating. Alas while sane Jason is restrained for his 'paranoia', the real madmen are the doc's genetic experiment outfit, who abuse their human captives as live incubators for a giant spider's eggs...—KGF Vissers

After the deadly first encounter with the hairy army of arachnids in Spiders (2000), the brilliant scientist, Dr Grbac, continues to conduct illegal genetic tests on spiders in his state-of-the-art floating laboratory. Everything goes smoothly, until the stranded young couple, Jason and Alexandra, set foot in the open-sea vessel, and witness firsthand the scientist's hospitality. As wounded Jason is injected with unstable spider-DNA, he becomes the perfect host for his top-secret experiment, and Alexandra is next. Now, yet another multitude of killer-spiders is lurking in the ship's dark corners, feeding off fear and succulent human flesh. The hunt is on. Who can stop the spiders' feeding frenzy?—Nick Riganas