As tensions between mankind and the mutants begin to rise, Spider-Man discovers that the sinister Green Goblin has a hand in the escalating conflict.

As conflicts begin to rise between the mutant and human communities of New York, Spider-Man must find a way to de-escalate the rising tensions before this powder keg explodes. His investigation leads him to the Green Goblin and the secrets of Oscorp Industries. All the while, our hero also tries to win back his ex-girlfriend Gwen Stacy.