It follows the story of three women who discover that they are sisters. Julia finds out that her Nobel prize winning father secretly used his own sperm in a number of "In Vitro Fertilisation" procedures.

Suffering from a terminal illness, IVF pioneer Julius Bechly (Barry Otto) makes a horrifying confession from his deathbed. His award winning career as a fertility specialist was propped up by the use of his own sperm. Julius' one legitimate child, the well-intentioned but chaotic Julia (Maria Angelico), makes it her mission to set the record straight and compensate for her father's scandalous admission. Welcoming new siblings into her life with open arms, Julia discovers a sea of brothers, but only two sisters: troubled children's television star, Roxy Karibas (Lucy Durack), and belligerent lawyer, Edie Flanagan (Antonia Prebble). Thrown together by biology, Julia, Roxy and Edie's lives suddenly collide. While Julia relishes the prospect of gaining new family, Roxy senses a fresh career opportunity, and Edie cannot see past the crime that has been committed.

Sisters follows the story of Julia Bechly whose life is turned upside down when her father, IVF pioneer Julius Bechly, makes a death-bed confession that during his award-winning career as a fertility specialist he used his own sperm and admits he could potentially be the father of hundreds of children. Julia decides to take most of the situation and throws a family gathering where she finds out she has hundreds of brothers, but learns she only has two sisters, troubled children's television star, Roxy Karibas and belligerent lawyer, Edie Flanagan.