When a mad scientist hybridizes the genes of a killer whale and a wolf, this creates the whalewolf and, once again, it is up to the sharktopus to stop it.

Picking up where Dr. Nathan Sands and Dr. Rico Symes left off after the two previous destructive experiments with animal DNA in the films Sharktopus (2010) and Sharktopus vs. Pteracuda (2014), yet another scientist, this time Dr. Elsa Reinhardt, decides yet again to play with fire. It seems that some people never learn, and when the ambitious doctor decides to cross the genes of a killer whale and a wolf, she inadvertently creates the uncontrollable hybrid monstrosity named the whalewolf. Now, as the alcoholic boat captain Ray and his partner Pablo leave no stone unturned to locate the sharktopus that roams free in the waters of the Dominican Republic, the nightmarish whalewolf wreaks havoc on the land. But what happens when these two unstoppable beasts cross paths?—Nick Riganas

A scientist, Dr. Elsa Reinhardt, crosses the genes of a killer whale and a wolf, creating a hybrid monstrosity named the whalewolf. Clearly the only answer is to locate something equally hybridized and monstrous, the sharktopus, and use it to kill the whalewolf.—grantss