Strange things start happening when a withdrawn girl named Lain becomes obsessed with an interconnected virtual realm known as "The Wired".

Lain Iwakura, an awkward and introverted fourteen-year-old, is one of the many girls from her school to receive a disturbing email from her classmate Chisa Yomoda-the very same Chisa who recently committed suicide. Lain has neither the desire nor the experience to handle even basic technology; yet, when the technophobe opens the email, it leads her straight into the Wired, a virtual world of communication networks similar to what we know as the internet. Lain's life is turned upside down as she begins to encounter cryptic mysteries one after another. Strange men called the Men in Black begin to appear wherever she goes, asking her questions and somehow knowing more about her than even she herself knows. With the boundaries between reality and cyberspace rapidly blurring, Lain is plunged into more surreal and bizarre events where identity, consciousness, and perception are concepts that take on new meanings.

A week after Chisa committed suicide, her classmates begin to receive emails from her. Hearing rumors fly at school, a quiet withdrawn girl named Lain goes home that day, turns on her dusty Navi computer for the first time and has a conversation with the dead girl. Chisa's message reads that she killed herself because she didn't need her body anymore, and she now exists in The Wired. When Lain asks why someone would do something like that she gets a response: "Because God is here".—Anonymous