A group of people around the world are suddenly linked mentally, and must find a way to survive being hunted by those who see them as a threat to the world's order.

Sense8 tells the story of eight strangers: Will (Smith), Riley (Middleton), Capheus (Ameen), Sun (Bae), Lito (Silvestre), Kala (Desai), Wolfgang (Riemelt), and Nomi (Clayton). Each individual is from a different culture and part of the world. In the aftermath of a tragic death they all experience through what they perceive as dreams or visions, they suddenly find themselves growing mentally and emotionally connected. While trying to figure how and why this connection happened and what it means, a mysterious man named Jonas tries to help the eight. Meanwhile, another stranger called Whispers attempts to hunt them down, using the same sensate power to gain full access to a sensate's mind (thoughts/sight) after looking into their eyes. Each episode reflects the views of the characters interacting with each other while delving deeper into their backgrounds and what sets them apart and brings them together with the others.—Soumik Ghosh

A group of strangers all experience a rebirth which inexplicably links them intellectually emotionally and sensually we are taken along their journey to discover exactly what they are going through witnessing their interactions from face to face conversations from opposite sides of the world without the use of any devices, using each other's skills and abilities, learning about each other, all the while being pursued by a secretive group that wish to lobotomise them in order to prevent a evolutionary path they do not wish to become humanity's future.

The story of Sense8 begins when the psychic connection of eight strangers from different cultures and parts of the world is "birthed" by a woman called Angelica, who kills herself to avoid capture by a man named "Whispers". The eight eventually discover they now form a cluster of "sensates": human beings who are mentally and emotionally linked, can sense and communicate with each other, and can share their knowledge, language, and skills. In the first season, the eight-Capheus, Sun, Nomi, Kala, Riley, Wolfgang, Lito and Will-are shown trying both to live their everyday lives and to figure how and why they are connected. Meanwhile, a sensate named Jonas, who was involved with Angelica, comes to their aid, while the Biologic Preservation Organization (BPO) and Whispers, a high-ranking sensate inside BPO, attempt to hunt them down. In the second season, the eight have grown accustomed to their connection and help each other on a daily basis. They learn more about Homo sensorium (the scientific name of sensates), the history and goals of BPO, the role of Angelica in it, and their powers and how to temporarily suspend them. They also meet other sensates, not all of whom are friendly. At the same time, Jonas attempts to both aid them and look after himself after being captured by Whispers, who is now involved in a cat-and-mouse game with Will, each of them trying to outsmart the other.—ahmetkozan