In this sequel to Ratten - sie werden dich kriegen! (2001), Frank and Katrin return to Frankfurt to take on a pack of genetically mutated vermin. When the the rodents attack, it's up to Frank and Katrin to stop the scientist responsible for the mutant critters.

Get ready for a terrifying tale when a deadly rat plague begins sweeping the nation. After a woman is found bitten to death, Frank and Katrin, who helped defeat the pack of rats in the first rat plague, know something is wrong. And when the rats begin to attack other residents, it is up to them to find the deranged scientist responsible for the genetically mutated rodents - before it is too late.