A narco kingpin escapes from a high-security Mexican prison with his son and finds refuge at a remote drug rehab facility located on the U.S. side of the border where they encounter deadly mutant zombies.

Narcos vs Zombies follows the story of legendary narco kingpin Alonso Marroquin (Peris-Mencheta), who escapes from a high-security Mexican prison with his son Lucas (Nery Arredondo) and finds refuge hiding at Paradiso, a remote drug rehab facility located on the U.S. side of the border. Meanwhile, test subjects from a failed U.S. military experiment -intended to transform wounded soldiers into killing machines- are left for dead near the border, only to revive as deadly mutant zombies. In its pursuit of the runaway Marroquins, the Mexican SWAT team is infected by the newly-created zombies, becoming a zombie army in its own right. Alerted of the imminent threat that this new species represents to humanity, the U.S. Army embarks on a mission to annihilate them.