Set during the 1970s, Italian and American authorities are closing in on three prominent figures of organized crime. These men decided to flee to Brazil, seeking refuge with new identities and a fresh objective: to "tropicalize" the mafia.

Rio Connection takes place in the mid-1970s, when Italian and American authorities were closing in on three prominent figures of organized crime. On the run, the three men found themselves in Brazil, with new identities and a new goal: tropicalize the mafia.