Dudley (Booger) Dawson is about to get married, but the father of the bride doesn't want his daughter to marry a nerd. The nerdy gang needs to set things straight once again.

Lewis and his nerdy friends attend Booger's wedding to the daughter of a rich Republican, but nerd-haters in the family do everything possible to prevent the wedding going ahead. Meanwhile, Lewis awaits with eagerness the birth of his unborn foetal child...—Sunil Iyer <[email protected]>

Madly in love with Jeanie, the beautiful daughter of a wealthy aspiring politician, Booger can't wait to walk down the aisle with his Omega Mu sweetheart. Of course, the father, who opposes this union, is bent on preventing a tragedy, and to make matters worse, when rampant nerds arrive for the ceremony, including Stan Gable after the events of Revenge of the Nerds III: The Next Generation (1992), Jeanie and Booger's marriage is hanging by a thread. Now, the legendary Tri-Lambs will have to do what they do best, and thwart a sinister conspiracy in the name of love. Who can stand in the way of the young couple's happiness?—Nick Riganas