Residents at the hospital, doctors, friends and their families are constantly threatened by Dr. Greg Cooper who may be the Homicide killer, avenging on all of them because he was dropped from the hospital's intern program.

Spin-off of "General Hospital" focusing on the professional and personal lives of the first year interns at Port Charles' General Hospital. Now residents at the hospital, the doctors and their friends and families are constantly threatened by Dr. Greg Cooper who may or may not be the General Homicide killer. Cooper tries to get revenge on all of them because he was dropped from the hospital's intern program.—Adam-157

Port Charles is a city located somewhere in New York, that seems to be a magnet for the forces of evil. Currently the city is being taken over by Vampires and is in complete chaos! If you are into vampires, angels, slayers, and all around crazyness then Port Charles is the show for you, not to mention 7 emmy noms and several great actors and actresses.—flagchickNCHS